Cellular iron: Ferroportin is the only way out
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منابع مشابه
Is rationing the only way out?
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Maintaining physiologic iron concentrations in tissues is critical for metabolism and host defense. Iron absorption in the duodenum, recycling of iron from senescent erythrocytes, and iron mobilization from storage in macrophages and hepatocytes constitute the major iron flows into plasma for distribution to tissues, predominantly for erythropoiesis. All iron transfer to plasma occurs through t...
متن کاملCardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function.
Iron is essential to the cell. Both iron deficiency and overload impinge negatively on cardiac health. Thus, effective iron homeostasis is important for cardiac function. Ferroportin (FPN), the only known mammalian iron-exporting protein, plays an essential role in iron homeostasis at the systemic level. It increases systemic iron availability by releasing iron from the cells of the duodenum, s...
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The ubiquitination and destruction of cyclins provides the way out of mitosis. A multiprotein complex polyubiquitinates cyclin B and promotes the separation of sister chromatids.
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ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2005
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2005.02.005